We have previously shown that significant circadian oscillations exist for cardiac troponin T (cTnT) but not for cardiac troponin I (cTnI).
Cardiac myosin-binding protein C (cMyC) is a novel protein biomarker of myocardial injury with a promising role in the diagnosis and risk stratification of acute myocardial injury.
In this study, we examine and compare the diurnal variation of cMyC with cTnT/I.
In this study, we examine and compare the diurnal variation of cMyC with cTnT/I.
cMyC was measured by Millipore Sigma. Limit of detection 0.4 ng/L, limit of quantitation (20% analytical coefficient of variation) of 1.2 ng/L; intra-series precision (CV, 11 +/− 3%), and inter-series precision (CV, 13 +/− 3%), 99th percentile is 87 ng/L. cTnT (Roche hs-cTnT) and cTnI (Abbott hs-cTnI) were measured previously by Klinkenberg et al., but data were reanalyzed and are represented here to enable direct comparisons with cMyC.