Patented biomarker for cardiac injury. 

Kinetics of cardiac myosin binding protein c after cardiopulmonary bypass

Cardiac myosin binding protein C (cMyC) is a novel biomarker of myocardial injury that has been shown to rise and fall faster than cardiac troponins after a defined ischaemic insult. Previous work has compared the two biomarkers starting at 6 hours after coronary artery bypass grafting. However, the kinetics in the early period after revascularisation are unknown and early assessment of myocardial injury might allow intervention for high risk cases. Our objective was to assess the kinetics of cMyC release in the first 6 hours after cross clamp release.
When compared with high-sensitivity troponin, cMyC concentrations showed greater inter-individual variability but rose to a level that was statistically distinguishable from baseline at the 3 hour timepoint, as opposed to 5 hours for the more established biomarker, high-sensitivity troponin.
cMyC kinetics after cardiopulmonary bypass
cMyC kinetics after cardiopulmonary bypass