Tag: cMyBP-C
- M. Yildirim, C. Salbach, B.R. Milles et al
Incorporating cMyBP-C and hs-cTnT - effectively rules out AMI, showing non-inferiority to hs-cTnT-only-based rapid rule-out algorithms and offers a promising alternative, potentially enhancing clinical decision-making in emergency settings.
- Debabrata Dutta, Vu Nguyen, Kenneth S. Campbell, Raúl Padrón & Roger Craig
Here we solve the structure of the main (cMyBP-C-containing) region of the human cardiac filament using cryo-electron microscopy. The reconstruction reveals the architecture of titin and cMyBP-C and shows how myosin’s motor domains (heads) form three different types of motif (providing functional flexibility), which interact with each other and with titin and cMyBP-C to dictate filament architecture and function.
- Samantha Harris
Cardiac myosin binding protein-C (cMyBP-C) is a critical regulator of heart muscle contraction.