cMyC^®

Cardiac Specific Biomarker

Patented biomarker for cardiac injury.

cMyC^®

Cardiac Specific Biomarker

Patented biomarker for cardiac injury.

Landmark publications

A 0/1h-algorithm using cardiac myosin-binding protein C for early diagnosis of myocardial infarction

Thomas E. Kaier, Raphael Twerenbold, Pedro Lopez-Ayala et al

Direct Comparison of cMyC With Cardiac Troponins for the Early Diagnosis of Acute Myocardial Infarction

Thomas E. Kaier, Raphael Twerenbold, Christian Puelacher, et al.

Circulation
(2017)

Identification of cMyC as a Candidate Biomarker of Myocardial Infarction by Proteomics Analysis

Sebastien Jacquet, Xiaoke Yin, Pierre Sicard, et al.

Molecular & Cellular Proteomics
(2009)

Webinars

A new diagnostic marker on the horizon – cMyC

C. Mueller, N. Mills & M. Marber

ESC (European Society of Cardiology)
(2021)

Stop making waves: A new regulatory role for cardiac myosin binding protein-C in contraction

Samantha Harris

Fralin Biomedical Research Institute
(2019)

Research & Reviews

Comparing combined testing of cMyBP-C and hs-cTnT with other algorithms for rapid rule-out of acute myocardial infarction in suspected acute coronary syndrome patients

M. Yildirim, C. Salbach, B.R. Milles et al

European Heart Journal
(2024)

Associations of Cardiac myosin binding protein C to Troponin I in patients with chronic heart failure during exercise. A substudy of the SMARTEX-HF trial

E Riveland, A Ushakova, T Valborgland, et al

European Heart Journal
(2024)

Insights into the Novel Cardiac Biomarker in Acute Heart Failure: MyBP-C

Adriana Chetran, Minerva Codruta Bădescu, Ionela Lăcrămioara Serban, et al

MDPI journals
(2024)

Kinetics of cardiac myosin binding protein c after cardiopulmonary bypass

Tom Gilbey, Liam Couch, Bashir Alaour, et al

Direct Comparison of the Circadian Rhythm of Cardiac Myosin-Binding Protein C (cMyC) and Cardiac Troponin

Bashir Alaour, Thomas E Kaier, Rasmus Bo Hasselbalch, et al

The Journal of Applied Laboratory Medicine
(2023)

Anthracyclines and Biomarkers of Myocardial Injury: The Effect of Remote Ischemic Conditioning (RIC)

Michael Mallouppas , Robin Chung , Arjun K. Ghosh , Alison Macklin , Derek M. Yellon , and J. Malcolm Walker

American College of Cardiology
(2023)

Phosphorylation and fragmentation pattern of cMyC for the differentiation between different types of myocardial injury

Bashir Alaour, Yu Jin Chung, Thomas Edward Kaier et al

Cardiac Biomarker Kinetics and Their Association With Magnetic Resonance Measures of Cardiomyocyte Integrity Following a Marathon Run: Implications for Postexercise Biomarker Testing

Vincent L. Aengevaeren , Roland R. J. van Kimmenade , Jordi Ordóñez‐Llanos , et al.

Journal of the American Heart Association
(2021)

Biological variation of cardiac myosin-binding protein C in healthy individuals

Bashir Alaour, Torbjørn Omland, Janniche Torsvik, et al

Clinical Chemistry and Laboratory Medicine
(2021)

Cardiovascular Biomarkers in the Early Discrimination of Type 2 Myocardial Infarction

Thomas Nestelberger, Jasper Boeddinghaus, Pedro Lopez-Ayala, et al

JAMACardiology
(2021)

Cardiac Myosin‐Binding Protein C in the Diagnosis and Risk Stratification of Acute Heart Failure

Nikola Kozhuharov, Desiree Wussler, Thomas Kaier, et al.

Wiley Online Library
(2021)

cMyC to Diagnose Acute Myocardial Infarction in the Pre‐Hospital Setting

Thomas E. Kaier, Carsten Stengaard, Jack Marjot, et al.

Journal of the American Heart Association
(2019)

Cardiac Myosin-Binding Protein C Release Profile After Cardiac Surgery in Intensive Care Unit

Xiang-Jian Chen, Wei Zhang, Zhi-Ping Bian, et al.

The Annals of Thoracic Surgery
(2019)

cMyC—From Bench to Improved Diagnosis of Acute Myocardial Infarction

Thomas E. Kaier, Bashir Alaour, Michael Marber.

Cardiovascular Drugs and Therapy
(2019)

Derivation and validation of a 0/1h-algorithm to diagnose myocardial infarction using cMyC – direct comparison to hs-cTnI

T E Kaier, R Twerenbold, B Alaour, et al.

European Heart Journal
(2018)

cMyC: how a novel biomarker could transform chest pain triage

Thomas E Kaier, Bashir Alaour, Michael Marber.

Future Medicine
(2018)

Cardiac myosin-binding protein C is a novel marker of myocardial injury and fibrosis in aortic stenosis

Atul Anand, Calvin Chin, Anoop S V Shah, et al.

Temporal Relationship between cMyC and cTnI in Type 1 Myocardial Infarction

Thomas E Kaier, Atul Anand, Anoop S V Shah, et al.

Clinical Chemistry
(2016)

Scientific background

Cryo-EM structure of the human cardiac myosin filament

Debabrata Dutta, Vu Nguyen, Kenneth S. Campbell, Raúl Padrón & Roger Craig

Nature
(2023)

Structure of the native myosin filament in the relaxed cardiac sarcomere

Davide Tamborrini, Zhexin Wang, Thorsten Wagner, et al

Nature
(2023)

Cardiac myosin-binding protein C as a biomarker of acute myocardial infarction

Michael S Marber, Nicholas L Mills, David A Morrow, Christian Mueller, et al

2020 ESC Guidelines for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation

Jean-Philippe Collet, Holger Thiele, et al.

European Heart Journal
(2020)

From bench to improved diagnosis of AMI – cMyC

Thomas E Kaier, Raphael Twerenbold, Carsten Stengaard, et al.

BMJ - Heart
(2018)

Quantifying the Release of Biomarkers of Myocardial Necrosis from Cardiac Myocytes and Intact Myocardium

Jack Marjot, Thomas E Kaier, Eva D Martin, et al.

Clinical Chemistry
(2017)

The development and application of a high-sensitivity immunoassay for cMyC

Jack Marjot, Christoph Liebetrau, Robert J. Goodson, et al.

Translational Research
(2015)

Cardiac myosin-binding protein C: a potential early biomarker of myocardial injury

James O. Baker, Raymond Tyther, Christoph Liebetrau, et al.

Basic Research in Cardiology
(2015)

Media & Blogs

A new diagnostic marker on the horizon – cMyC

C. Mueller, N. Mills & M. Marber

ESC (European Society of Cardiology)
(2021)

Stop making waves: A new regulatory role for cardiac myosin binding protein-C in contraction

Samantha Harris

Fralin Biomedical Research Institute
(2019)

UK Researchers Eye Alternative POC Test to Troponin to Quickly Rule Out Heart Attack

Leo O'Connor

360Dx
(2018)

Is cMyC the new troponin?

Rick Body.

St.Emlyn’s
(2017)

Blood test will tell if you’ve had a heart attack within 15 minutes of arriving at A&E: Rapid test found to be twice as accurate as existing one

Ben Spencer

Mail online
(2017)

‘Instant’ blood test for heart attacks

BBC

BBC
(2017)

New heart attack test could save NHS millions of pounds every year

Kings College London

Kings College London
(2017)

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